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Brain Informatics (BI) is an emerging interdisciplinary and multi-disciplinary research field that focuses on studying the mechanisms underlying the human information processing system (HIPS). BI investigates the essential functions of the brain, ranging from perception to thinking, and encompassing such areas as multi-perception, attention, memory, language, computation, heuristic search, reasoning, planning, decision-making, problem-solving, learning, discovery, and creativity. One goal of BI research is to develop and demonstrate a systematic approach to an integrated understanding of macroscopic and microscopic level working principles of the brain, by means of experimental, computational, and cognitive neuroscience studies, as well as utilizing advanced Web Intelligence (WI) centric information technologies. Another goal is to promote new forms of collaborative and interdisciplinary work. New kinds of BI methods and global research communities will emerge, through infrastructure on the wisdom Web and knowledge grids that enables high speed and distributed, large-scale analysis and computations, and radically new ways of data/knowledge sharing.