ИСТИНА

subcortical infarctions and leukoencephalopathy (CADASIL) is an inherited central nervous system disease, which is caused by NOTCH3 gene mutations. Also diffuse white matter changes and leukoaraiosis can be observed. Major neuroimaging characteristics of CADASIL with white matter hyperintensities are presented at pic.1. The mean age of the disease onset is approximately 30-40 years. Frontal lobe dysfunction, slowness of the processing speed, attention and motor control disturbances, impairment in the executive and visuospatial functions, memory loss have been described in CADASIL. Also gustatory or auditory hallucinations and “clouding of consciousness” may be presented. Objectives.– White matter is an anatomical base of inter-analyzer interaction (IAI); it provides the connection between different cortex zones of analyzers systems. Clinical psychology does not have any developed methodology of experiments and tools for IAI research. It is important to investigate this interaction and disorders in neurological and psychiatric diseases involving disorders of the integrative brain activity, in particular IAI. Methods.– Uznadze’s method of fixed set can be applied to identify and analysis of IAI disorder in patients with the white matter pathology, as irradiation of set from one modality to another is impossible without inter-analyzer connections. Results/conclusions.– Experimental research design included eight patients with CADASIL disease and ten healthy subjects. In both groups statistically valuable differences are obtained (U = .0001; P≤0003). Such methodology can be used as an objective tool to assess the grade of safety IAI for diagnostic of white matter brain pathology. Disclosure of interest.– The authors have not supplied their declaration of competing interest.