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The background of a problem of metaphysics of life of the nature and the person is shown. Its current state in philosophical, religious and is natural-scientific directions is analyzed.Metaphysics definition as kernels of spiritual theoretical activity — sets of the creatives-eidoses which are a basis of research programs of a science – are revealed. Seven are allocated binarnoconnected metaphysical programs of the Antiquity, the basic directions which have defined further of scientific researches. The special attention is given antique representations about the beginning of a life and internal spiritual activity of the person. In the project evolution of doctrines about a life in philosophy is revealed, and also the problem of an origin and essence of a life in the light of achievements in the physicist is analyzed, biology and chemistry of XX century Now philosophers and scientists discuss such metaphysical principles, as so-called principles of a synergy and nature self-organizing (I. Prigogine,G.Haken). The metaphysical status of principles of invariance and recurrence is revealed and the question on them numerical operations in a modern science is analyzed. Critically has been analyzed modern reduction the approach of data of properties of live organisms to signs and characteristics of an inorganic matter. The new status of a problem of a life as experimentally metaphysical and necessity of its further working out in philosophical and in natural-science directions is noted.