ИСТИНА

Tin (IV) complexes are perspective candidates for the creation of specific anticancer drugs. Analysis of cytotoxic activity of such compounds is one of the first steps in studying the properties of potential drugs. Сytotoxicity of organotin complexes with Sn–S bonds of formulae Ph3SnSR (1) Ph2SnSR (2), [1] (R=3,5-di-tert-butyl-4-hydroxyphenyl) and RSH against human breast (MCF-7) was determined. It was shown that the mechanical addition of RSH to the test compounds 1, 2 in a ratio of 1: 2 and 2: 1 does not affect the cytotoxic activity of the compounds. It is established that the usage of mechanical mixtures of compounds 1 and 2 has the combined effect on the survival of MCF7 cells (Fig. 1, 2). Similarly, to the studies carried out on the Bacillus thuringiensis with Ph3SnCl, it can be assumed that the investigated compounds 1, 2 interact not with the secondary and tertiary structure of the protein, but with certain amino acids (methionine, glutamate, lysine, alanine, leucine, valine, aspartate). The interaction spectra can be different, but it is possible for them to overlap. This fact explains sophisticated interaction, the nature of which can be "additivity + synergy”. Additivity probably prevails at the low concentrations and synergism - at the high ones.