ИСТИНА

Nanoparticles (NPs) represent one of the most effective drug delivery systems suitable for most administration routes. Poly(lactic acid), poly(glycolic acid) (PLA) and their copolymers (PLGA) have been extensively investigated for the preparation of drug nanocarriers because of their biocompatibility, biodegradability, controlled and sustained- release properties (Mir M. et al. Colloids Surf B Biointerfaces. 2017) and which are supplied by quite a few manufacturers. One of the key factors defining therapeutic efficacy of NPs is the release rate (or profile) of the drug. It is highly likely that insignificant differences in the polymer properties can substantially influence the properties of NPs: it is the molecular weight distribution and acid values of polymers that ultimately define the encapsulation efficiency of the drug, its release rate and the NPs degradation rate.