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Results of biochemical (EMSA) and fluorescence microscopy studies showed that NIR-ODN imaging probe was specific for NF-kB both in cell cytoplasm and nuclei of pancreatic cells. The binding to nuclei and cytoplasmic fraction of pancreatic islet cells correlated with the increased NF-kB activity/expression after MLD-STZ treatment damage to the pancreas. The tested NIR probe is not species-specific and can be used in studies of various animal models of diabetes as well as other inflammatory disease.