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It was demonstrated that NIR duplex probe, specific for functional NF-κB heterodimer: 1) has sufficient sensitivity to functional NF-κB in non-fixed islets and tissues, 2) distinguishes between NF-κB expression in pre-diabetic vs. control pancreas by using FI and FLT techniques. The obtained results are highly relevant to future in vivo translation via NIR imaging of NF-κB activity in the pancreas. The tested NIR duplex probe is not species-specific and has applications in various animal models of inflammatory disease.
№ | Имя | Описание | Имя файла | Размер | Добавлен |
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1. | Презентация | TT_WMIC_2018.pdf | 1,5 МБ | 14 декабря 2018 [MetelevV] |