ИСТИНА

Monoamine oxydase (MAO), as a catabolic enzyme, regulates monoamine transmitter levels in the central nervous system. The activity of this enzyme is genetically regulated. The gene encoding the A form of human monoamine oxidase enzyme (MAOA) is located on the short arm of X chromosome. One of the common polymorphisms is a 30 bp functional VNTR polymorphism (MAOA-uVNTR). In this study, we examined distribution of the MAOA-uVNTR polymorphism in groups of elite athletes of different specialization. 100 athletes and 105 non-trained controls were genotyped. Analysis of this test reveals that the frequency of MAOA alleles differ between groups of complex-coordination, playing and endurance kind of sport. Frequency of high active allele increases in groups of complex-coordination and endurance sportsmen. Frequency of low active allele decreases in groups of complex-coordination and playing sportsmen. Interrelation of MAOA genotype and athletic successfulness are discussed.