ИСТИНА

The precise detection of tumor borders including dense cancer and infiltrated peritumoral regions is the crucial task to achieve the successive tumor removal with the minimal surgical intervention. Raman spectroscopy with 633 and 785 nm laser excitation was already shown to distiguish between normal cortex and dense cancer regions, however, there is still lack of the accuracy in the detection of borders of the infiltrated peritumoral regions. We demonstrate that Raman spectroscopy with laser excitations at 633 and 532 nm allows to discriminate between normal cortex and tumor (dense cancer, grade 2-4 glioma) and to visualize the infiltration of glioma cells in the peritumoral region.