ИСТИНА

Krushinsky-Molodkina (KM) rat strain was the first one in the range of similar genetic models, created in the late 1940s. When exposed to loud sound develop clonic (in 2-3 sec) and tonic (in 7-10 sec) convulsions. The daily sound exposure results in 15-12 days) with the development of myoclonic seizures, starting with face muscle jerks spreading to neck and body musculature. This phenomenon was described in other audiogenic prone rat strains and represents the typical seizure kindling. As the TLE symptoms in humans include also numerous rather serious psychiatric disorders (apart from myoclonus fits) the KM rat strain could represent the model of complicated changes development in brain structures similar and parallel to those in humans (when the long history of generalized seizures invokes the TLE symptoms). The behavioral peculiarities defects in KM rats could be noted in locomotion, anxiety signs and tendency to develop the catalepsy – both spontaneous and post-ictal. The short seizure development latencies and the possibility to reproduce seizures in the same animals made these animals the valuable tool for study the seizure modulation factors – e.g. strong olfactory stimulation and antiepileptic drugs. The developmental aspects of audiogenic epilepsy is also promising when this strain is used as the genetic model of seizure propensity.