ИСТИНА

According to the World Health Organization in 2010, more than 16 million people are caused by infectious and parasitic diseases, which are mainly transmitted from sick animals that transmit these diseases. The total number of diseases and deaths from intestinal helminthiases is higher than from bacterial, viral and other parasitic diseases combined. In this regard, the problem of combating animal helminthiasis is a national task. Currently, methods of treating animal helminthiases are based on the use of a wide range of anthelmintic drugs, some of which often do not provide the necessary effectiveness and often their use can cause unwanted side effects that are harmful to animal health. One of the reasons for the low effectiveness of benzimidazole anthelmintic drugs is the low solubility of their substances in water and physiologically active media. In this regard, it is necessary to overestimate the dosage of these drugs, thereby causing many undesirable consequences: overdose of the active substance and overpricing of the drug, increase in toxicity and environmental damage, etc. We have proposed an innovative approach to increase the solubility of poorly soluble anthelmintic substances by mechanochemically modifying them using water-soluble polymers, including plant metabolites (polysaccharides, saponins, etc.). The essence of the method is that they conduct joint solid-phase mechanical treatment of the substance of a medicinal substance with a plant metabolite in grinders-activators with controlled energy intensity. Obtained according to the proposed technology, the preparations had increased anthelmintic activity with a decrease in the consumption rate of active substances by 2- 10 times. The report will present examples and solutions to the above problems.