ИСТИНА

Considering the main and most effective link in the fight against animal helminthiasis is deworming using anthelmintic drugs of various chemical nature, the development and research of new anthelmintic agents remain one of the urgent problems of veterinary medicine. This position is also important because helminths, like other biological objects - parasites, microorganisms, etc., are characterized by adaptation to the action of certain drugs, including anthelmintics, which suggests the need for a systematic update and expansion of the anthelmintic arsenal. At present, a number of highly effective, low-toxic benzimidazole drugs (including albendazole, fenbendazole, mebendazole, etc.) with a wide spectrum of anthelmintic action have been developed and are widely used in veterinary practice. One of the disadvantages of these drugs is their low solubility in water and physiological environments of their substances, which does not allow their effective use, namely, part of the drug is excreted from the body before it dissolves and exhibits the necessary biological effect. Along with economic aspects, environmental problems arise with environmental damage. To improve the solubility and bioavailability of such drugs, we are conducting research on the development of drugs in a series of benzimidazole drugs by mechanochemical modification of their substances with plant metabolites (polysaccharides). The aim of the work was to conduct research, including the development, improvement and study of the anthelmintic activity of innovative benzimidazole drugs (albendazole, fenbendazole) obtained by mechanochemical modification using polysaccharides such as arabinogalactan and chitosan. According to the results of the studies, it was found that the solubility of drugs based on albendazole increased by 20 times, fenbendazole by 14 times, which suggested an increase in anthelmintic action. Test data of anthelmintic activity showed that preparations at a dose of 5 mg / kg had a rather high anthelmintic effect on the main, most widespread, helminths of sheep (marshallagia, nematodiruses, other gastrointestinal strongilates, moniesia and fascioli) and they could be recommended for use in veterinary practice.