ИСТИНА

The use of probe microscopy techniques for the detection of biological macromolecules is a relatively new direction. We propose biosensor for viruses, bacteria and proteins detection. In particular, for detection of influenza A virus were used sialic acids as the biospecific recognition reagents to bind to hemagglutinin of the virus. For bacterial cells detection, the antibodies against surface antigenic determinants of the cells are placed on the sensory layer surface. Detection of biological agents in the biosensor is carried out by registration of the amplitude, phase, frequency and the quality factor of the mechanical vibrations of the piezoceramic biochip.