ИСТИНА

Spatial pre-organization of the components of a receptor and a guest molecule is a key factor governing the proper 3D arrangement of the participants of the supramolecular assemblies. Several quite effective classes of supramolecular host systems like crown-ethers, calixarenes, cucurbituriles are well-known. We would like to pay attention to 3,7- diazabicyclo[3.3.1]nonanes, aka «bispidines». In these systems one could easily functionalize almost all positions of the bicyclic core, particularly, both nitrogens and carbon at position 9, aiming to decorate the molecule for fulfilling the desired task. During the lecture the listeners will have an opportunity to look at our recent results on the study of the properties of various bispidine-based systems (conformations, biological activity, radiocopper, gels, chiral ligands, etc.) [1,2], including their use to support the concept of «stereoelectronic chameleons» [3]. The authors are grateful to the Russian Science Foundation for the financial support of these studies (grant 19-73-20090). REFERENCES 1. Vatsadze et al: Mendeleev Commun 1999, 3, 87-88; Tetrahedron 2014, 70, 7854-7864; Mendeleev Commun 2016, 26, 212-213; ACS Omega, 2016, 1(5), 854-867; Nanomaterials 2019, 9, 89-106. 2. Volcho et al: Med Chem Res 2015, 24, 4146-4156; Russ J Bioorg Chem 2015, 41(6), 657- 662; Bioorg Med Chem Lett 2017, 27, 4531-4535. 3. Alabugin, Vatsadze et al: Chem Eur J 2017, 23(14), 3225-3245; JACS 2018, 140(43), 14272-14288