ИСТИНА

New materials based on Au, Ag and Cu nanoparticles stabilized in a matrix of bacterial cellulose (BC) were prepared for medical applications. Au, Ag and Cu nanoparticles were synthesized by metal vapor synthesis (MVS) and incorporated into BC using metal-containing organosol1,2. Bacterial cellulose films were synthesized by Gluconacetobacter hansenii producer strain. The materials were characterized by transmission and scanning electron microscopy (TEM, SEM) and X-ray photoelectron spectroscopy (XPS). XPS results showed that for metal-containing composites one Au 4f7/2-Au 4f5/2 spin-orbit doublet at 83.87 and 87.52 eV and Ag 3d5/2 - Ag 3d3/2 spin-orbit doublet at 368.22 - 374.22 eV with a splitting of 6.0 eV are observed, which indicates the state of Au0and Ag0 respectively. TEM data showed BC stabilized metal particles nanoformations having “a grape bunch” structure, in which smaller metal particles are combined. The antibacterial activity against some Gram-positive and Gram-negative microorganisms (Escherichia coli, Bacillus coagulans and Staphylococcus Aureus) and the antitumor effect of the new metal-containing nanocomposites have been determined.