ИСТИНА

α-Ketocyclopropanes are abundant in both natural compounds and pharmaceuticals and represent versatile precursors with wide applicability in organic synthesis. Polyspirocyclic cyclopropane-containing compounds are of special interest in terms of their structure, physical and chemical properties. In this connection, the aim of the work was to investigate new synthetic approaches to unknown polycyclic cyclopropylketones. The proposed approach to α-ketocyclopropanes starting from ketones includes sequential methylenation, cyclopropanation and direct oxidation of methylene group activated by adjacent cyclopropane moiety. In the course of this approach, cyclopropane-containing hydrocarbons 3,6 were obtained from the corresponding diketones and investigated in oxidative conditions. As a result, the series of previously unknown polycyclic cyclopropylketones with cyclooctane core were obtained.