ИСТИНА

The pyrimidine scaffold is known to be present in a number of natural compounds and drugs. The pyrimidine derivatives are widely used in target-oriented synthesis of biologically active compounds and novel materials. Developed in our laboratory synthetic approaches to pyrimidine derivatives as well as the methods of functionalization of heterocyclic ring provide an opportunity to obtain the heterocycles with a variety of substituents as a platform for drug discovery. Using our universal synthetic methodology a large series of novel pyrirmidine derivatives possessing antiviral, anticancer or neuroprotective type of activities was obtained from readily available staring compounds.