ИСТИНА

Introduction Anxiety and depressive disorders are often common in essential hypertension (EH). It can be caused by a malfunction of the medial temporal lobe (Shimoda & Kimura, 2014). Objectives To assess the relationships of the medial temporal lobe dysfunctions with the data on the features of emotion regulation (ER) in EH patients. Methods The degree of vascular dysfunction in the brain cortical areas was assessed with the method for assessing cerebrovascular reactivity in a hyperventilation fMRI test (Vartanov et. al., 2015; 2017). Brain fMRIs have been obtained using a MR-scanner Siemens Skyra 3T. A study of emotionality and ER was performed using 16PF Questionnaire, Ways of Coping Questionnaire (WCQ), Cognitive Emotion Regulation Questionnaire (CERQ). The study involved 16 naive middle-age patients with uncomplicated EAH, stage 1-2, average age is 53.4 ± 6.3. Results It was found that only vascular dysfunctions in the BA 36 (the ectorhinal cortex) correlate with the results of ER tests: 1. The degree of vascular dysfunction in the right BA 36 correlates with values on the ‘C’ scale (Emotional Stability) in 16PF (r=-0.62, p<0.01), as well as with the Coping strategy “Planful problem solving” (r=0.38, p <0.005). 2. The degree of vascular dysfunction in the left BA 36 correlates with the ‘O’ scale (Apprehension) (16PF) (r=-0.63, p <0.01) and with the ER “Positive reappraisal” in CERQ (r = 0.40, p <0.005). Conclusions Interhemispheric asymmetry of the BA 36 participation into the ER of EH patients was revealed. The research was supported by RFBR; project № 17-06-00954.