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Microscopic Analyses of Liquid-Liquid Phase Separation Induced by Linker Histone H1.0доклад на конференции
- Авторы: Geraskina Olga, Maluchenko Natalya, Studitsky Vasily, Gerasimova Nadezhda, Koshkina Daria, Feofanov Alexey
- Международная Конференция : Криоэлектронная микроскопия 2021: достижения и перспективы (RUSSIAN INTERNATIONAL СONFERENCE ON CRYOELECTRON MICROSCOPY 2021; RICCEM2021)
- Даты проведения конференции: 30 мая - 2 июня 2021
- Дата доклада: 2 июня 2021
- Тип доклада: Стендовый
- Докладчик: Geraskina Olga
- Место проведения: Москва, Russia
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Аннотация доклада:
Liquid-liquid phase separation (LLPS) that leads to the formation of temporary functional domains in cells plays an important role in the processes of chromatin condensation and gene regulation. Earlier, it was demonstrated that histone H1.4 can form LLPS droplets with DNA. In the present work, LLPS was studied for histone H1.0, which is mainly expressed in differentiated and non-dividing cells. H1.0 is involved in cancer development: its amount decreases with the progression of tumor cells to malignancy
- Добавил в систему: Малюченко Наталия Валериевна