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The mixed micelles on the basis of Tween 80 (Tw) are found to be efficient carriers of felodipine (antihypertensive lipophilic drug, F) and of glyceryl monooleate or glyceryl monolaurate (skin permeability enhancer, En) in aqueous media. Different properties of micelles (Tw + F, Tw + En, Tw + En + F) such as numbers of molecules of each component, diffusion coefficients, sizes and degree of hydration were studied.