ИСТИНА

Using methods Pd(0)-catalyzed macrocyclization reactions, macrocycles with C2-chiarl fragment of 1,1’-binaphthalene-2,2’-diamine (BINAM) were synthesized in good yields. These compounds differ by the nature of the aryl spacer, the length of the oxadiamine linker and the number of oxygen atoms in it. The macrocycles were modified with two 5-(dimethylamino)-1-sulfonamide (dansyl) fluorophore groups using convenient nucleophilic substitution reactions, and with two 6-aminoquinoline fluorophore groups using the Pd(0)-catalyzed amination reactions. The yields of the fluorophore-decorated ligands were found to be dependent on the nature of the starting macrocycles and reached 99% in the case of dansyl substituents and 73% in the case of quinolinyl substituents.