ИСТИНА

Animal Parasitic diseases represent a major scientific and economic problem, which is caused by the prevalence of parasitic diseases that cause great economic losses and damage to health. Farm animals in some regions up to 70-80% are infected with parasites that cause significant reduction in productivity and often death of the animals. To solve this problem requires the development of anthelmintic drugs with high efficacy and safety for the organism. Treatment of parasitic diseases is carried out mainly by foreign drugs or drugs produced in Russia on the basis of imported substances. Therefore, studies are highly relevant for the development of innovative domestic anthelmintic drugs. We have developed technology of mechano-chemical modification of a number of substances known anthelmintics with hydrophilic polymers, which act as delivery systems for drug molecules (DrugDeliverySystems / DDS /). This solves an important task - to increase the solubility of these substances, which by their nature are classified as bad-and water-insoluble organic molecules. As a result of our technology has improved solubility, permeability, bioavailability and efficacy of these substances led to decrease in the effective dose 5-10 times. In addition, the observed expansion of the range of action of drugs and reducing consumption rates previously used imported substances. High anthelmintic effect developed systems was achieved by increasing membrane permeability and improved drug delivery of molecules to the active sites of the body corresponding receptors using innovative approaches DDS. The properties of these delivery systems depend on many factors, and is mainly determined by a complex composition such as "host-guest", and production technologies. The advantages of the technology is the ability to produce these complexes for systems that do not have a total area of solubility. Thus, failure in the technology of the use of solvents or melts reduces the likelihood of undesirable side reactions. The proposed technology is scalable and allows to achieve high performance (up to 100 kg per hour of dry matter), it is based on a relatively simple equipment, designed and produced in the Russian Federation and non-waste production. These results open up the prospect of accelerated creation of a broad spectrum drugs having increased therapeutic efficacy and safety on the basis of already authorized for use of drugs. Production of such products will allow for significant substitution of the use of imported drugs.