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The Application of a Novel Biomaterial Based on the Secreted Products of Human Mesenchymal Stromal Cells for Spermatogenesis Restoration in the Model of Experimental Cryptorchidismдоклад на конференции
- Авторы: Sagaradze G.D., Makarevich P.I., Makarevich O.A., Efimenko A.Yu, Basalova N.A., Kamalov D.M., Nimiritsky P.P.
- Международная Конференция : XXIV Международная научная конференция студентов, аспирантов и молодых ученых "Ломоносов – 2017"
- Даты проведения конференции: 20 апреля 2017
- Дата доклада: 11 апреля 2017
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: МГУ имени М.В.Ломоносова, Russia
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Аннотация доклада:
Couple infertility is a severe medical condition and it is often caused by male infertility. Development of novel approaches to recover spermatogenesis is actual due to the lack of effective therapeutic instruments. Multipotent mesenchymal stromal cells (MSC) play crucial role in reparation and regeneration processes in an organism. Along with other functions they secrete many biological factors (MSC conditioned medium, MSC-CM) activating endogenous tissue- specific stem and progenitor cells. MSC produce a wide spectrum of growth factors and cytokines necessary for spermatogenesis maintenance. Thus, secreted products of MSC can be the promising instrument to restore spermatogenesis. We developed combined biomaterial to provide optimal delivery and release of these products.
- Добавил в систему: Сагарадзе Георгий Дмитриевич