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The immunochemical methods based on the specific and high affinity antibodies are widely used for high-throughput screening (HTS) and monitoring of organic compounds. At first it is important for detection of poisons and toxic organic chemicals like: pesticides, detergents, endocrine disrupters (EDC), dyes, mycotoxins, explosive and etc. The Enzyme-Linked Immunosorbent Assay (ELISA) is one of widely used immunoassays. Moreover, ELISAs are modified to make its more simple, quick and cheap without any instruments or with using available device like smart phone. Recent trend for development and application of new immunochemical methods will be given. More details could be found in our recent publications and reviews.