ИСТИНА

The development of effective ferrocene-containing porphyrins is a modern area for effective drugs researching. Recent studies1 revealed an cytotoxic activity of ferrocene-modified porphyrins under sonication in vitro, making them potential sonosensitizers for sonodynamic therapy. Here, a method developed for obtaining ferroceneporphyrins by a nucleophilic substitution of an acetate group in ferrocenylcarbinols with the 5-(p-aminophenyl)-10,15,20-triphenylporphyrin (H2TPP-NH2). Available ferrocenylcarbinols chosen as starting compounds, the OH group of which was replaced by an acetate one under acylation with acetic anhydride in anhydrous pyridine. Hybrid ferrocene-porphyrins 3a-d obtained by the interaction of ferrocenyl(alkyl/aryl)acetates 1a-d with H2TPP-NH2 2 in toluene with the addition of K2CO3. The dependence of the reaction progress on the substituent in the initial ferrocene derivative was revealed (Fig.1). Thus, in the case of ferrocenylmethanol acetate, bis-ferrocenyl derivative of porphyrin was isolated as the main product, the reaction with methyl and isopropyl substituents gives the target ferrocene-porphyrins, when using ferrocenyl(phenyl)acetate bis-ferrocenylphenyl, ether was isolated as the main product. Further biological studies are planned.