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Biological Behavior in vitro of Alpha-Fetoprotein and its sub domain labeled by 99mTcдоклад на конференции
- Авторы: Korsunsky V., Klementyeva O., Bruskin A., Rabinovich E., Egorov O., Rodionov S., Oschepkov V.
- Международная Конференция (Конгресс) : EANM'10 - Annual Congress of the European Association of Nuclear Medicine
- Даты проведения конференции: 9-13 октября 2010
- Дата доклада: 9 октября 2010
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Вена, Австрия
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Аннотация доклада:
Human alpha-fetoprotein (AFP), a tumor-associated foetal glycoprotein of 70 kDa, has been recognized for long time as a clinical marker for both foetal distresses as well as for some types of human tumors. It was postulated that growth of some tumor cells occurs, among others, through the interaction of AFP with cell surface receptors. Because breast adenocarcinoma expresses receptors for AFP, we studied 99mTc radiolabeled AFP and its sub domain (AFP-D) as agents to detect breast cancer. The aim of this work was to evaluate the accumulation and internalization radiolabeled AFP and its sub domain in tumor cells in vitro.
- Добавил в систему: Клементьева Ольга Евгеньевна