ИСТИНА

The use of chemiluminescence as a source of light for photodynamic therapy of tumors allows overcoming the limitations caused by difficulties in delivering light through absorbing and diffusing tissues. One of possible endogenous source of light is peroxyoxalate chemiluminescent (PO-CL) reaction. This reaction proceeds between active derivatives of oxalic acid and hydrogen peroxide. It is known that increased production of hydrogen peroxide is characteristic for inflamed tissues and cells of some tumors. The present study was aimed at creating polyoxalatecontaining dispersions capable of eliminating tumor cells through the PO-CL reaction with endogenous hydrogen peroxide. Tetramethyl hematoporphyrin (TMHP) included into the dispersions acted as an activator in PO-CL reaction as well as an effective photosensitizer for singlet oxygen generation and illumination of cells, thus avoiding a superfluous step of energy transfer from activator to photosensitizer.