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Toxicity influence of heavy metal ions with large ionic radii ( like Pb2+(1,2 Å),Rb+(1,47 Å), Cs+(1,65 Å), Eu++ (1,33 Å),. Gd3+ (0,98Å) and etc.) on living organisms are discussed on the base of the physical mechanisms of metal ions interactionwithcharged macromolecules – proteins and enzymes. The behavior of some proteins (like protein of serum blood and fibrillar protein like collagen) and some enzymes - pepsin, collagenase, lyzozyme,creatincenase in water solutions in the presence of different toxic metals ions at the very low concentrations of the salts were investigated by the used some optical methods - Laser light scattering (photon correlation spectroscopy) , fluorescence spectroscopy and polarized fluorescence.Interaction of the proteins and enzymes in solutions containing heavy metal ions results in the formation of large (nano size) clusters.These processes can to disturb metabolic processes in the organism ( celles, membranes, plasma blood ). The nanoparticle formation molecular mechanism is considered in terms of dipole-dipole and charge-charge interaction of the macromolecules in its water shells