ИСТИНА

Rodent audiogenic epilepsy (AE) is the complicated polygenic trait, and several selected for AE proneness were described for rats, mice and hamsters. The neurophysiology of AE was analyzed in details, while its “comorbidity” with other pathological states, as well as the developmental regulation are not clear. In rats of Krushinsky-Molodkina (KM) inbred strain AE seizures develop in 100% of individuals with minimal latency (5-7 srec for tonic seizure stage). Aiming to define the genetics of AE two new rat strains were bred recently (from hybrids of KM and non-AE-prone Wistar) using two back-crossed to KM parental strain. One of them (“0” strain) was selected for lack of AE seizure, while another (“4” strain) - for intense AE seizure. The genetic analysis data of the first hybrid generations permitted to confirm the recessive polygenic nature of AE genetic determination (describing at least two genes-modifiers). This panel of strains permitted to analyze the influence of maternal methyl-enriched diet (which decreased AE in “4” strain, but not in KM), as well as to describe the detailed pattern of comorbid and non-comorbid traits (i.e. anxiety and depression), which prove that the comorbidity in this seizure model depends largely on the influence of the genetic background (as “0”, “4” and KM are more closely related than Wistar). Biology Department, Moscow State University, Moscow, Russia. Country Funding Support: RFBR (grant # 15-04-1732), and The Program N AAA-A16-11602166005-1.