ИСТИНА

The Krushinsky-Molodkina rat strain is the important member of audiogenic prone rat strains group. The strain selection started in 1947 on the basis of local Wistar population. Now KM is the inbred strain with the history of more than 40 generations of close brother-sister matings. The 100% of KM rats develop the prompt generalized clonic-tonic seizures after 5-9 sec of loud sound exposure (bell sound, 120dB). The clonic-tonic seizures of KM rats are preceded by the typical wild-run stage, which is typical for audiogenic epilepsy, which is also known as “clonic run”. At the same time after the end of seizure fit the intense post-ictal catalepsy develops in KM rats (the specific state of body muscle tone). The repetitive daily sound exposure results in the emergence (after 12-18 daily sessions) of different type of seizures of another category - myoclonic seizures. The single but prolonged sound exposure – 15 minutes of repetitive loud and weak 10 s sounds resulted in paresis and palsy symptoms and sometimes of animal death, which are the consequences of brain circulation disorders. The valuable data were obtained on the numerous anticonvulsant drugs although laboratory model needs now the new group of comparison as Wistar and KM rats were bred separately for a long time. Aiming to create it the new rat strain was selected for the “absence of audiogenic fit” (strain “0”), which was initiated on the basis of KM x Wistar (with two backcrosses on KM strain). The parallel audiogenic seizure prone strain (strain “4”) was selected as well, and this triade was already tested in pharmacological experiments with chronic fluoxetine treatment as the example. It was demonstrated that no comorbidity of anxiety, depression and audiogenic seizures were detected when several rat genotypes were investigated.