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Study of triplet periodicity differences inside and between genomesстатья
- Авторы: Suvorova Yulia M., Korotkov Eugene V.
- Журнал: Statistical Applications in Genetics and Molecular Biology
- Том: 14
- Номер: 2
- Год издания: 2015
- Издательство: Berkeley Electronic Press
- Местоположение издательства: United States
- DOI: 10.1515/sagmb-2013-0063
- Аннотация: Triplet periodicity (TP) is a distinctive feature of the protein coding sequences of both prokaryotic and eukaryotic genomes. In this work, we explored the TP difference inside and between 45 prokaryotic genomes. We constructed two hypotheses of TP distribution on a set of coding sequences and generated artificial datasets that correspond to the hypotheses. We found that TP is more similar inside a genome than between genomes and that TP distribution inside a real genome dataset corresponds to the hypothesis which implies that a common TP pattern exists for the majority of sequences inside a genome. Additionally, we performed gene classification based on TP matrixes. This classification showed that TP allows identification of the genome to which a given gene belongs with more than 85% accuracy.
- Добавил в систему: Коротков Евгений Вадимович