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Design of a sensor for the blood AB0 group antibodies detectionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 9 июля 2015 г.
- Авторы: Kolesov D.V., Kiselev G.A., Moiseev M.A., Kudrinskiy A.A., Yaminskiy I.V.
- Сборник: Journal of Physics Conference Series
- Серия: Conference Series
- Том: 345
- Год издания: 2012
- Издательство: IOP Publishing
- Местоположение издательства: [Bristol, UK], England
- Номер статьи: 012042
- DOI: 10.1088/1742-6596/345/1/012042
- Аннотация: Control the content of the blood group antibodies in the plasma of the recipient is an important task in modern transplantation. In this paper we proposed to use micromechanical cantilever sensors for detection of the low concentrations of AB0 blood group antibodies in serum. The technique of chemical modification of cantilever surface to create the receptor layer was developed. The apparatus, which provides data acquisition from multiple microconsoles simultaneously was created. We carried out experiments by the detection in a solution the β antibodies with a concentration of 300 times less than the native content of antibodies in the blood. Change in surface stress due to formation of antigen-antibody complexes on the cantilever surface was 0.075 N/m. The resulting lateral strain, apparently, induced by repulsion between the complexes during the sorption of antibodies in layer of antigens, immobilized on the surface. The possibility of regeneration of sensory layer for repeated measurements was shown.
- Добавил в систему: Колесов Дмитрий Валерьевич