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Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid statusстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Lee Byung Cheon, Kaya Alaattin, Siming Ma, Kim Gwansu, Gerashchenko Maxim V., Yim Sun Hee, Zhen Hu, Harshman Lawrence G., Gladyshev Vadim N.
- Журнал: Nature communications
- Том: 5
- Год издания: 2014
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- DOI: 10.1038/ncomms4592
- Аннотация: Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.
- Добавил в систему: Гладышев Вадим Николаевич