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A functional link between housekeeping selenoproteins and phase II enzymesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Sengupta Aniruddha, Carlson Bradley A., Weaver James A., Novoselov Sergey V., Fomenko Dmitri E., Gladyshev Vadim N., Hatfield Dolph L.
- Журнал: Biochemical Journal
- Том: 413
- Номер: 1
- Год издания: 2008
- Издательство: Portland Press, Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 151
- Последняя страница: 161
- DOI: 10.1042/bj20080277
- Аннотация: Sec (selenocysteine) is biosynthesized on its tRNA and incorporated into selenium-containing proteins (selenoproteins) as the 21st amino acid residue. Selenoprotein synthesis is dependent on Sec tRNA and the expression of this class of proteins can be modulated by altering Sec tRNA expression. The gene encoding Sec tRNA (Trsp) is a single-copy gene and its targeted removal in liver demonstrated that selenoproteins are essential for proper function wherein their absence leads to necrosis and hepatocellular degeneration. In the present study, we found that the complete loss of selenoproteins in liver was compensated for by an enhanced expression of several phase II response genes and their corresponding gene products. The replacement of selenoprotein synthesis in mice carrying mutant Trsp transgenes, wherein housekeeping, but not stress-related selenoproteins are expressed, led to normal expression of phase II response genes. Thus the present study provides evidence for a functional link between housekeeping selenoproteins and phase II enzymes.
- Добавил в систему: Гладышев Вадим Николаевич