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Contact activation of blood coagulation: trigger properties and hysteresis. Kinetic recognition of foreign surfaces upon contact activation of blood coagulation: a hypothesisстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 декабря 2015 г.
- Авторы: Pokhilko A.V., Ataullakhanov F.I.
- Журнал: Journal of Theoretical Biology
- Том: 191
- Номер: 2
- Год издания: 1998
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 213
- Последняя страница: 219
- DOI: 10.1006/jtbi.1997.0584
- Аннотация: A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hysteretic manner. Within a range of relatively small signals, two (activated and non-activated) stable states coexist (bistability). Signals of the natural environment (surfaces of endothelial and blood cells) seem to be in the range of bistability; therefore, contact activation that persists for a short time can induce a transition of the system to the activated state, and, correspondingly, the formation of a clot. The system cannot return to the initial state, which is characterized by low activation levels, until the activating signals decrease significantly below those present in the circulation
- Добавил в систему: Атауллаханов Фазоил Иноятович