Synthesis and antimicrobial properties of 5,5′-modified 2′,5′-dideoxyuridinesстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:An effective method of synthesis of 5,5'-modified 2',5'-dideoxyuridine derivatives is based on sequential 5'-iodination and azidation of 5-[4-(1-decyl)-1,2,3-triazol-1-yl]methyl-2'-deoxyuridine followed by 1,3-dipolar cycloaddition of the intermediate azide with an olefin under the catalysis of Cu(I) resulting in 75-85% yield of 5'-[4-substituted (1,2,3-triazol-1-yl]-5-[4-(1-decyl)-1,2,3-triazol-1-yl]methyl-2',5'-dideoxyuridine. The compounds were shown to possess low cytotoxicity in Vero, A549 cells and Jurkat cell cultures and did not demonstrate noticeable antimicrobial activity.