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Comparative analysis of associations between polymorphic variants of the F2, F5, GP1BA, and ACE genes and the risk of developing stroke in Russian and Ukrainian populationsстатья Исследовательская статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 4 сентября 2018 г.
- Авторы: Tupitsyna T.V., Bondarenko E.A., Kravchenko S.A., Tatarskyy P.F., Shetova I.M., Shamalov N.A., Kuznetsova S.M., Shul’zhenko D.V., Skvortsova V.I., Slominsky P.A., Livshits L.A., Limborska S.A.
- Журнал: MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY
- Том: 28
- Номер: 1
- Год издания: 2013
- Первая страница: 8
- Последняя страница: 14
- DOI: 10.3103/S0891416813010072
- Аннотация: We performed comparative analysis of associations between the F2 gene G20210A polymorphism, the F5 gene G1691A polymorphism, the GP1BA gene -5T/C polymorphism, the ACE gene insertion/deletion (I/D) polymorphism and the risk of developing stroke in two samples drawn from ethnic Russian and ethnic Ukrainian populations. It has been shown, that among the Russian population, the risk of developing ischemic stroke is increased in DD genotype individuals (odds ratio (OR) = 1.4, 95% confidence interval (CI) [1.05; 1.78], p = 0.02), whereas the I/I and I/D genotypes are associated with a decreased risk of developing stroke (OR = 0.7, 95% CI [0.56; 0.95], p = 0.02). In the ethnic Ukrainian sample, differences in the distribution of genotypes and allele frequencies between stroke patients and the control group of subjects with regard to this polymorphic locus are statistically unreliable and the ACE gene I/D polymorphism is unassociated with the risk of developing stroke in the Ukrainian population (OR = 0.8, 95% DI[0.48; 1.32], p = 0.45). The F2 gene G20210A polymorphism, the F5 gene G1691A polymorphism, and the GP1BA gene -5T/C polymorphism are unassociated with stroke risk factor across both ethnic samples.
- Добавил в систему: Бондаренко Елена Александровна