|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Investigation of stratum corneum lipid model membranes with free fatty acid composition by neutron diffractionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Ryabova N.Y., Kiselev M.A., Dante S., Hauss T., Balagurov A.M.
- Журнал: European Biophysics Journal
- Том: 39
- Год издания: 2010
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 1167
- Последняя страница: 1176
- DOI: 10.1007/s00249-009-0569-z
- Аннотация: The outermost epidermal layer Stratum corneum (SC) exhibits the main skin barrier. Studies of the SC model systems enable to characterize the influence of individual lipids on the organization of the SC lipid matrix, which is the main pathway of water through the skin. This work presents a neutron diffraction study of the SC model membranes based on short-chain ceramide 6 with nearly realistic composition of free fatty acids (FFA) at physiological temperature of the SC. The influence of FFA and the effect of cholesterol-cholesterol sulfate substitution on the structure and hydration of the SC model membranes have been described. The structure of the SC membrane with FFA is close to the structure of the earlier studied SC membrane based on short-chain palmitic acid (PA) and does not vary significantly under changes of the main membrane components ratio. FFA accelerates the membrane swelling at the same low level of hydration of both PA- and FFA- containing membranes. The substitution of cholesterol sulfate by cholesterol in the membrane composition decreases the membrane swelling and leads to phase separation in the model system.
- Добавил в систему: Самойлова Наталия Юрьевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Ryabova_EBJ.pdf | 306,1 КБ | 23 октября 2012 [nataliya_ryabova] |