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Organosilicon-based synthesis of new functionalized methylenediphosphonic acids as perspective bioactive compoundsтезисы доклада
- Авторы: Prishchenko A.A., Alekseyev R.S., Livantsov M.V., Novikova O.P., Livantsova L.I., Petrosyan V.S.
- Сборник: 101st Canadian Chemistry Conference and Exhibition
- Серия: 49th Silicon Symposium
- Тезисы
- Год издания: 2018
- Место издания: Edmonton, Alberta, Canada
- Первая страница: P-Si-17
- Аннотация: Functionalized methylenediphosphonic acids and their derivatives with aromatic and heterocyclic moieties are well-known biomimetics of hydroxy- or aminocarboxylic acids and natural pyrophosphates, and some of them such as zoledronic, risedronic, and minodronic acids are widely used in medicine. Organosilicon-mediated synthesis of functionalized organophosphorus acids and their derivatives was used recently by us as convenient method of creating of P-C bonds. We have synthesized the new functionalized methylenediphosphonic acids and their derivatives 1 including aromatic, azaheterocyclic, and amino acids moieties via addition of tris(trimethylsilyl) phosphite to corresponding formamides
- Добавил в систему: Прищенко Андрей Анатольевич