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In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligandsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Berger I., Hanif M., Nazarov A.A., Hartinger C.G., John R.O., Kuznetsov M.L., Groessl M., Schmitt F., Zava O., Biba F., Arion V.B., Galanski M., Jakupec M.A., Juillerat-Jeanneret L., Dyson P.J., Keppler B.K.
- Журнал: Chemistry - A European Journal
- Том: 14
- Номер: 29
- Год издания: 2008
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 9046
- Последняя страница: 9057
- DOI: 10.1002/chem.200801032
- Аннотация: The synthesis and in vitro anticancer activity of dihalogenido(η 6-p- cymene)(3,5,6-bicyclophosphite-α-D- glucofuranoside) ruthenium(II) complexes are described. The compounds were characterized by NMR spectroscopy and ESI mass spectrometry, and the molecular structures of dichlorido-, dibromido- and diiodido(η6-p-cymene)(3,5,6- bicyclophosphite-1,2-O-isopropylidene-α-D-glucofuranoside)-ruthenium(II) were determined by X-ray diffraction analysis. The complexes were shown to undergo aquation of the first halido ligand in aqueous solution, followed by hydrolysis of a P-O bond of the phosphite ligand, and finally formation of dinuclear species. The hydrolysis mechanism was confirmed by DFT calculations. The aquation of the complexes was markedly suppressed in 100 mM NaCl solution, and notably only very slow hydrolysis of the P-O bond was observed. The complexes showed affinity towards albumin and transferrin and monoadduct formation with 9-ethylguanine. In vitro studies revealed that the 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-α-D-glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC50 values from 30 to 300 μM depending on the cell line). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
- Добавил в систему: Назаров Алексей Анатольевич