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Tissue factor pathway inhibitor: a possible mechanism of actionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Panteleev Mikhail A., Zarnitsina Veronica I., Ataullakhanov Fazoil I.
- Журнал: European journal of biochemistry / FEBS
- Том: 269
- Номер: 8
- Год издания: 2002
- Издательство: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
- Местоположение издательства: Oxford, UK, England
- Первая страница: 2016
- Последняя страница: 2031
- Аннотация: We have analyzed several mathematical models that describe inhibition of the factor VIIa-tissue factor complex (VIIa-TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa-TFPI complex is the inhibitor of the extrinsic tenase activity. However, the model based on this hypothesis could not explain well all the available experimental data. Here, we show that a good quantitative description of all experimental data could be achieved in a model that contains two more assumptions. The first assumption is based on the hypothesis originally proposed by Baugh et al. [Baugh, R.J., Broze, G.J. Jr & Krishnaswamy, S. (1998) J. Biol. Chem. 273, 4378-4386], which suggests that TFPI could inhibit the enzyme-product complex Xa-VIIa-TF. The second assumption proposes an interaction between the X-VIIa-TF complex and the factor Xa-TFPI complex. Experiments to test these hypotheses are suggested.
- Добавил в систему: Пантелеев Михаил Александрович