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Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activityстатья
- Авторы: Kisil S.I., Chernikov V.A., Danilevskiy M.I., Savvateeva L.V., Gorokhovets N.V.
- Журнал: Engineering (Scientific Research Publishing)
- Том: 4
- Номер: 10
- Год издания: 2012
- Издательство: Scientific Research Publishing, Inc.
- Местоположение издательства: [Irvine, CA], United States
- Первая страница: 80
- Последняя страница: 83
- DOI: 10.4236/eng.2012.410b021
- Аннотация: The recombinant third domain of alpha-fetoprotein (AFP3D) is one of the promising vectors for targeted delivery of anticancer drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents have shown specific anti-tumor activity. The content of anti-tumor drugs in the preparation could be increased by including dendrimers - highly branched nanoparticles - into a targeted delivery system. In this study, we synthesized the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer nanoparticles and investigated its cytotoxic activity.
- Добавил в систему: Кисиль София Ивановна