An Interactive Method of Anatomical Segmentation and Gene Expression Estimation for an Experimental Mouse Brain Slice

Авторы: Anton Osokin, Dmitry Vetrov, Alexey Lebedev, Vladimir Galatenko, Dmitry Kropotov, Anokhin Konstantin V.
Сборник: Computational Intelligence Methods for Bioinformatics and Biostatistics - 7th International Meeting, September 16-18, 2010
Тезисы
Год издания: 2010
Место издания: Palermo, Italy
Первая страница: 86
Последняя страница: 97
DOI: 10.1007/978-3-642-21946-7_7
Аннотация: We consider the problem of statistical analysis of gene expression in a mouse brain during cognitive processes. In particular we focus on the problems of anatomical segmentation of a histological brain slice and estimation of slice’s gene expression level. The first problem is solved by interactive registration of an experimental brain slice into 3D brain model constructed using Allen Brain Atlas. The second problem is solved by special image filtering and further smart resolution reduction. We also describe the procedure of non-linear correction of atlas slices which improves the quality of the 3D-model significantly.
Добавил в систему: Анохин Константин Владимирович

	ИСТИНА	Войти в систему Регистрация
	ФНКЦ РР
	Главная Поиск Статистика О проекте Помощь

ИСТИНА