Аннотация:A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The approach involves the immobilization of these compounds on water-soluble polymers having a lower solution temperature and heating the delivery site above the critical temperature. The approach was verified with trypsin immobilized on N-isopropylacrylamide-acrylamide-N-acryloylphthalimide ternary copolymers.