Modeling of the cysteine-rich domain (CRD) of the metabotropic glutamine receptors

Авторы: Belenikin M.S., Palyulin V.A., Zefirov N.S.
Журнал: Doklady Akademii nauk SSSR
Том: 394
Номер: 2
Год издания: 2004
Издательство: Akademiia Nauk Sssr
Местоположение издательства: Russian Federation
Первая страница: 259
Последняя страница: 264
Аннотация: For C G-protein-conjugated receptors-class CRD the alignment is estimated and the first spatial model of CRD mGluR1-receptors is constructed, which is correlated with aminoterminal and transmembrane domains (AD and TD). Spatial alignment is characterized by two antiparallel β-layers (immunoglobulin β-sandwich. As concluded, CRD works as ’reducer’ decreasing shifts of TD α-helixes N-ends at AD conformational transformations. CRD also acts as intermediary at transmitting signal from AD to TD and can participate in fine modulation of receptor functioning.
Добавил в систему: Зефиров Николай Серафимович

	ИСТИНА	Войти в систему Регистрация
	ФНКЦ РР
	Главная Поиск Статистика О проекте Помощь

ИСТИНА