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Substituted 3-and 5-formylpyridin-2-ones in the synthesis of 1-aryl-1,6-naphthyridinone derivativesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
- Авторы: Medvedeva M.I., Tugusheva N.Z., Alekseeva L.M., Evstratova M.I., Kiselev S.S., Chernyshev V.V., Avramenko G.V., Granik V.G.
- Журнал: Russian Chemical Bulletin
- Том: 58
- Номер: 11
- Год издания: 2009
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 2336
- Последняя страница: 2346
- Аннотация: New 1-aryl-6-[2-(dimethylamino)vinyl]-4-oxo-1,4-dihydropyrimidine-5-carbonitriles and 4-arylamino-2-oxo-1,2-dihydropyridine-3-carbonitriles containing electron-withdrawing substituents in the benzene ring were synthesized from enamino amides and dimethylformamide dialkylacetals. The influence of various dimethylformamide acetals on the yield of 3-(4-chloroanilino)-2-cyano-5-(dimethylamino)penta-2,4-dienoic acid N-(dimethylamino)methylideneamide was investigated in the reaction of these acetals with 3-(4-chloroanilino)-2-cyanocrotonamide. New 4-arylamino-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitriles and 4-arylamino-2-oxo-1,2-dihydropyridine-3-carbaldehydes containing electron-withdrawing substituents in the benzene ring were synthesized. The latter compounds were converted into new substituted 1,6-naphthyridinones by the action of various CH acids. A new approach to the synthesis of 4-(4-fluoroanilino)-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitrile using dimethylformamide diisopropylacetal under mild conditions was developed. The comparative reactivity of the formyl group in the reactions of 4- arylamino-5-formyl-2-oxo-1,2- dihydropyridine-3-carbonitriles and in 4-arylamino-2-oxo-1,2- dihydropyridine-3-carbaldehydes with malononitrile was determined using HPLC.
- Добавил в систему: Чернышев Владимир Васильевич