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POLY(3-HYDROXYALKANOATE)-BASED DRUG FORMULATIONS: THE MICRO- AND NANOSTRUCTUREстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 мая 2019 г.
- Авторы: Bonartsev AP, Bonartseva GA, Voinova VV, Kirpichnikov MP, Shaitan KV
- Журнал: Bulletin of RSMU
- Номер: 6
- Год издания: 2018
- Издательство: Pirogov Russian National Research Medical University
- Местоположение издательства: Moscow
- Первая страница: 120
- Последняя страница: 124
- DOI: 10.24075/brsmu.2018.083
- Аннотация: Biodegradable and biocompatible polymers referred to as polyhydroxyalkanoates (PHAs) are extensively used in the production of pharmaceutical drugs to ensure sustained release, targeted delivery, reduced toxicity, and increased stability of the drug substance. Although the pharmaceutical industry ordinarily exploits chemically synthesized PHAs, bioengineered polymers are also starting to enjoy growing interest. This article focuses on the research and development of drug formulations based on natural PHAs that act as auxiliary substances for antibacterial, anti-inflammatory, anticancer, and hormonal medications, as well as pain killers, and discusses the association between their properties and the micro/nano structure of the synthetic drug. The problems associated with the poor performance of active components in traditional dosage forms can be overcome in PHAs-based formulations. Keywords: poly(3-hydroxyalkanoates), poly(3-hydroxybutyrate), microparticles, nanoparticles, nanostructure, sustained release
- Добавил в систему: Шайтан Константин Вольдемарович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | пдф | RGMU_2018-6-17_en.pdf | 626,4 КБ | 18 февраля 2019 [ShaitanKV] |