Macroporous composites with a complex framework based on calcium phosphate and biodegradable biopolymers

Zuev, D.; Klimashina, E.; Safronova, T.; Putlayev, V.; Evdokimov, P.

Авторы: Dmitry Zuev, Elena Klimashina, Tatiana Safronova, Valery Putlayev, Pavel Evdokimov
Сборник: yCAM 2019, Conference Abstracts, young Ceramists Additive Manufacturing Forum, April 3-5 2019
Тезисы
Год издания: 2019
Место издания: Université de Mons Mons, Belgium
Первая страница: 99
Последняя страница: 99
Аннотация: Modern regenerative medicine has a need in resorbable biocomposites as bone implants. Biodegradable polymers (polyc(ε-caprolactone) (PCL), poly(D,L-lactide) (PLA)) filled with resorbable calcium phosphates (with the ratio Ca/P ≤ 1.5, e.g., amorphous (ACP), mixed-anionic (maACP) and tricalcium phosphates (β-TCP)) can serve as such implants. Imperative feature of the materials is specific macroporous architecture (osteoconductivity) created by 3D-printing. In the case of thermal extrusion technique of 3D-printing (or, fused deposition modeling – FDM™), it is necessary to fabricate composite cords with uniform distribution of phosphate particles inside thermoplastic prior, to elaborate printing regimes, as well. The main goal is the development of such prototypes. Tasks include synthesis and physico-chemical studies of required calcium phosphates, 3D-printing of biocomposites β-TCP/(PCL,PLA), and modification of the composite surface. Determination the optimal parameters of 3D-printing technology for obtaining complex structures is important, as well. Composite β-TCP/PCL cords with different ratios (23% and 46%, 50% and 70%) β-TCP and with the different binding agent (vaseline oil and ethyl alcohol, respectively), as well as, β-TCP/PLA (20% and 50%) cords were formed. Macroporous structures with sizes of cells 16.5 × 16.5 × 4.5 mm; 30 × 30 × 3.5 mm, 10 × 10 × 2 mm, as well as, implants of a more complex shape with the Kelvin structure were produced by FDM printing. A change in the hydrophilicity of the surface of the obtained composite was demonstrated both by plasma treatment (500 V, 5 mA, AC, 5–15 minutes), and by soaking in 5·SBF solution, as well as, their combination. Thus, bioactive macroporous composites based on calcium phosphates and biopolymers were obtained. The possibility of obtaining osteoconductive implants based on polymers filled with resorbable calcium phosphate using thermal extrusion 3D printing has been shown. The work was funded by RFBR grant № 18-08-01473.
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