A-to-I RNA Editing: A Contribution to Diversity of the Transcriptome and an Organism’s Development

Zamyatnin, A.J.; Lyamzaev, K.; Zinovkin, R.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 апреля 2019 г.

Авторы: Zamyatnin AA Jr, Lyamzaev KG, Zinovkin RA
Журнал: Biochemistry (Moscow)
Том: 75
Номер: 11
Год издания: 2010
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1316
Последняя страница: 1323
DOI: 10.1134/S0006297910110027
Аннотация: The complexity of multicellular organisms requires both an increase in genetic information and fine tuning in regulation of gene expression. One of the mechanisms responsible for these functions is RNA editing. RNA editing is a complex process affecting the mechanism of changes in transcriptome sequences. The best studied example of this process is A-to-I RNA editing. On the organism's level, RNA editing plays a key role during ontogenesis and in the defense against pathogens. Disorders in A-to-I RNA editing lead to serious abnormalities. The importance of RNA editing increases with an increase in the organism's complexity. Correct RNA editing is an indispensable factor of an organism's development and probably determines the lifespan of higher eukaryotes.
Добавил в систему: Лямзаев Константин Геннадьевич

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A-to-I RNA Editing: A Contribution to Diversity of the Transcriptome and an Organism’s Developmentстатья

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