Mechanistic study of multi-step nucleophilic substitution for trifluoromethylated styrenesстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The key steps of the reactions of nitrogen nucleophiles with beta-halogen-beta-trifluoromethylstyrenes have been studied by F-19 and H-1 NMR monitoring and quantum-chemical calculations. In contrast to the mechanism proposed earlier for nucleophilic vinylic substitution of captodative carbonyl-bearing haloalkenes, this reaction proceeds via either E-Ad or Ad-E sequence depending on the nature of aromatic substituents of the parent styrenes. (C) 2011 Elsevier B.V. All rights reserved.